Chemistry Journal of Moldova

Accepted papers

Koba Amirkhanashvili, Alexandre Sobolev, Nani Zhorzholiani, Vladimer Tsitsishvili

Field: Inorganic and coordination chemistry
Type: Research paper
lidocaine complex, X-ray analysis, crystal structure, hydrogen bond.

 
Graphical Abstract: This paper reports on the synthesis and structure re-refinement of bis(lidocaine) diaquatetrathiocyanatonickelate(II). The compound with the formula (LidH)2[Ni(NCS)4(H2O)2], where Lid is (2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide, crystallizes in the monoclinic space group P21/c with a= 18.3509(5), b= 7.6532(2), c= 14.9585(4) Å, β= 109.964 (2)°, V= 1974.57 (9) Å3, and Z= 2. Coordination of the Ni2+ ion with thiocyanate ions and water molecules generates slightly distorted octahedral anion [Ni(NCS)4(H2O)2]2–  with N-bonded thiocyanate groups, while two protonated cations LidH+ remain in an outer coordination field. 


 

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Lauro Figueroa, Alejandra Garcimarero, Rolando Garcia, Francisco Diaz, Marcela Rosas, Virginia Mateu, Maria Lopez, Lenin Hau, Tomas Lopez, Abelardo Camacho, Yaritza Borges

Field: Organic chemistry
Type: Research paper
11
bicyclo, steroid, estrone derivative, synthesis.

 
Graphical Abstract: This study describes the preparation of two bicyclo[3.3.3]nonane-steroid derivatives from either estradiol or estrone using some reactions such as etherification, addition, nucleophilic substitution and cyclization. The chemical structure was evaluated through NMR spectroscopic analysis. The results showed higher yield for 11 compared with 12. It is noteworthy that the reagents used in this investigation are not expensive and do not require special conditions for handling.

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Hajer Hrichi, Nadia Ali Ahmed Elkanzi, Rania Badawy Bakr

Field: Organic chemistry
Type: Research paper
9
heterocycle, β-lactam, quinoxaline, antimicrobial activity, molecular docking.
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Graphical Abstract: A series of novel isolated β-lactams 3a-c and thiazolidinone derivatives 4a-c were successfully synthesized from reactions of new Schiff's bases 2a-c with chloroacetyl chloride and thioglycolic acid. The chemical structures of the new compounds were confirmed through different spectroscopic techniques including IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. The antimicrobial activity of the obtained compounds was assessed in-vitro against gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacteria and Aspergillus flavus and Candida albicans fungi. Furthermore, a molecular docking study was carried out and the results indicated that compounds 3b and 4b displayed comparable binding affinity scores as that of glutamate. These two compounds are promising candidates as antibacterial and antifungal agents that would deserve further investigations.



 

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