Chemistry Journal of Moldova

ONE-STEP SELECTIVE SYNTHESIS OF 13-EPI-MANOYL OXIDE

Author(s):

Olga Morarescu, Marionela Traistari, Alic Barba, Gheorghe Duca, Nicon Ungur, Veaceslav Kulcițki


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2021 Volume 16, no.1
Pages: 99-104
Keywords:

sclareol, cyclization, superacid, ether, labdane.


Full Text (PDF): Download

DOI: http://dx.doi.org/10.19261/cjm.2021.820

Abstract (PDF)
Supplementary Material (PDF)
Graphical Abstract: The selective one-step synthesis of 13-epi-manoyl oxide is reported based on a low-temperature superacidic cyclization of sclareol. The reaction conditions have been finely tuned in order to achieve a 9:1 ratio between epimeric oxides in favor of the desired 13-epi-oxide.


 

Downloads: 19