Chemistry Journal of Moldova

CHEMICAL COMPOSITION AND LIPOXYGENASE INHIBITORY ACTIVITY OF THE ESSENTIAL OIL OF ALSTONIA ANGUSTILOBA

Author(s):

Wan Mohd Nuzul Hakimi Wan Salleh, Muhammad Helmi Nadri, Shamsul Khamis


Field: Natural product chemistry and synthesis
Type: Short communication
Pages: 5
Keywords:

essential oil, hydrodistillation, lipoxygenase, Alstonia angustiloba, Apocynaceae.


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DOI: http://dx.doi.org/10.19261/cjm.2021.848
 
Graphical Abstract: This study was aimed to investigate the chemica l compositions and lipoxygenase inhibitory activity of the essential oil from Alstonia angustiloba growing in Malaysia. The essential oils were obtained by hydrodistillation and fully characterized by gas chromatography and gas chromatography-mass spectrometry. Analysis of the A. angustiloba essential oil resulted in the identification of twenty-five chemical components, attributed 90.8% of the total oil. The most abundant components of A. angustiloba oil were linalool (21.2%), 1,8-cineole (16.8%), α-terpineol (9.5%), terpinene-4-ol (8.5%), β-caryophyllene (6.2%), and caryophyllene oxide (5.2%). The essential oil displayed moderate activity towards lipoxygenase activity with IC50 value of 45.8 μg/mL. 



 

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