Chemistry Journal of Moldova

Natural product chemistry and synthesis

C15 FUNCTIONALIZED DERIVATIVES OF ent-KAUR-16-EN-19-OIC ACID: ISOLATION FROM THE SUNFLOWER HELIANTHUS ANNUUS L. AND SYNTHESIS

Author(s):

Marina Grinco, Olga Chetraru, Veaceslav Kulciţki, Alic Barba, Alexandr Boico, Pavel F. Vlad and Nicon Ungur


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2010 Volume 5, no.1
Pages: 106-108
Keywords: diterpene, isolation, synthesis, 15α-angeloyl-ent-kaur-16-en-19-oic acid, 15α-hydroxy-ent-kaur-19-oic acid, 15-oxo-ent-kaur-16-en-19-oic acid.
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SYNTHESYS OF A FUNCTIONALIZED TETRAHYDROFURAN FRAGMENT THROUGH BROMINATION-CYCLIZATION OF A CONJUGATED DIENE

Author(s):

Veaceslav Kulciţki, Marina Cara, Andrea Bourdelais, Tomas Schuster and Daniel Baden


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2010 Volume 5, no.1
Pages: 118-120
Keywords: Terpenoids, furans, NBS, conjugate addition.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2010.05(1).13

Graphical Abstract:
 Conjugate 1,4-addition of N-bromosuccinimide (NBS) to a diene system, possessing a suitable oxygen functionality, leads to functionalized  tetrahydrofuran derivatives, which can be further derivatized into different synthetic targets.


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A RETRO-BIOMIMETIC ONE-STEP SYNTHESIS OF NATURAL ATISANIC AND BEYERANIC DITERPENOIDS

Author(s):

Olga Chetraru, Marina Grinco, Veaceslav Kulciţki, Pavel F. Vlad and Nicon Ungur


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2010 Volume 5, no.1
Pages: 121-123
Keywords: Terpenoids, biomimetic synthesis, kaurane, atisane, beyerane.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2010.05(1).14

Graphical Abstract: 
The direct, one step conversion of ent-kaurenoic acid 3 into atisanic and beyeranic acids 1 and 2 was performed under the action of fluorosulfonic acid.

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CONTINUOUS EVOLUTION IN COLABORATIONS BETWEEN MOLDOVAN AND ITALIAN CHEMISTS

Author(s):

M. Gavagnin, V. Kulcitki


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 7-8
Keywords:
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DOI:
dx.doi.org/10.19261/cjm.2011.06(2).01

Moldovan chemists hosted the Italian partners in Chisinau and organized in premiere for the last 20 years an international seminar devoted to the chemistry of natural products. The seminar’s motto: New Frontiers in the Chemistry of Natural Products has addressed numerous students and researchers acting in the fields of chemistry, biology, pharmacy, genetics, biophysics as well as specialists from the R&D sector of companies with chemico-pharmaceutical profile. Following multiple solicitations coming from seminar audience, made us provide in the current issue of the  “Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry” a condensed abstract of the seminar presentations. We do really hope that our joint event will give further impetus to our collaboration and will also motivate other researchers from Moldova to develop partnerships with European colleagues.

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APPLICATION OF NMR TECHNIQUE IN THE ELUCIDATION OF MARINE NATURAL COMPOUNDS

Author(s):

M. L. Ciavatta


Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2011 Volume 6, no.2
Pages: 9-12
Keywords: NMR techniques, natural products, marine compounds.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2011.06(2).02

Graphical Abstract:
 The topic of the seminar held in the Institute of Chemistry, Academy of Sciences of Moldova on 30th September in the frame of the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, concerned the use of NMR techniques in the elucidation of natural products. Step by step, two marine compounds (Fulvyne C and Tritoniopsin A) belonging to different chemical classes have been analyzed, by using suitable NMR experiments. This powerful technique allowed the elucidation of compounds as fulvynes, long chain polyacetylenes with the same functional groups but differently located in the chain, as well as tritoniopsins, cyclic diterpenes with a new skeleton, providing further information on their relative and absolute stereochemistry.


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SYNTHESIS OF C6 AND C7 FUNCTIONALIZED DRIMANES FROM LARIXOL AND SCLAREOL

Author(s):

A. Ciocarlan, P. F. Vlad, M. Coltsa, C. Edu, A. Biriiac, A. Nicolescu and C. Deleanu


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 13-15
Keywords: natural product chemistry, larixol, sclareol.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2011.06(2).03

Graphical Abstract:
 The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 30 September. An overview of the synthetic methods oriented to the synthesis of C6 and C7 functionalized euryfurans is provided.


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PHARMACOLOGICAL AND MEDICINAL CHEMISTRY ASPECTS OF CANNABIS COMPOUNDS

Author(s):

T. Cotelea


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 16-18
Keywords: Cannabis compounds, metabolism, pharmacological action, phisico-chemical analysis.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2011.06(2).04

Graphical Abstract:
 The current communication includes a general overview of the scientific interest and medicianl chemistry aspects of Cannabis compounds. It relates to metabolism, pharmacological action and phisico-chemical analysis of these compounds, as well as of some isomers differing in spatial arrangement of functional groups.

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EXPLORING THE CHEMISTRY OF MARINE OPISTHOBRANCHS: RECENT RESULTS

Author(s):

Margherita Gavagnin


Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2011 Volume 6, no.2
Pages: 19-23
Keywords: natural product chemistry, marine opisthobranch molluscs, bioactive molecules.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2011.06(2).05

Graphical Abstract: 
The current communication is an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 30th September. An overview of the recent studies conducted by our group on opisthobranch molluscs from distinct geographical areas is briefly presented.


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SYNTHETIC APPROACHES TO POLIFUNCTIONALIZED PERHYDRINDANES

Author(s):

Veaceslav Kulciţki


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 24-26
Keywords: natural product chemistry, diterpenoids.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2011.06(2).06

Graphical Abstract:
 The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 31 September. An overview of the synthetic methods oriented to the synthesis of functionalized terpenic perhydrindanes is provided. Different synthetic strategies are considered, including those based on  biomimetic approach. The array of obtained new structures can serve as leads in structure-activity studies as well as useful building blocks towards other perhydrindanes.

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SYNTHETIC STRATEGY FOR THE PREPARATION OF BIOACTIVE GALACTOGLYCEROLIPIDS

Author(s):

Emiliano Manzo, Maria Letizia Ciavatta, Dario Pagano and Angelo Fontana


Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2011 Volume 6, no.2
Pages: 27-29
Keywords: Glycolipids, bio-medical applications, galactosyldiacylglycerols.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2011.06(2).07

Graphical Abstract:
 The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 30 September. A simple and efficient strategy for the synthesis of galactoglycerolipids is provided.

Downloads: 19