Chemistry Journal of Moldova

Organic chemistry

MOLECULAR CONCEPTS OF MACROPHAGE TARGETING

Author(s):

Veaceslav Boldescu, Valeriu Crudu, Natalia Sucman, Serghei Pogrebnoi, Marina Zviaghinţeva, Eugenia Stîngaci, Vsevolod Pogrebnoi, Fliur Macaev


Field: Organic chemistry
Type: Review
Issue: 2013 Volume 8, no.2
Pages: 21-31
Keywords: macrophage receptor targeting, macrophage enzyme targeting, inflammatory disorders, tuberculosis, cancer
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DOI:
dx.doi.org/10.19261/cjm.2013.08(2).02

Graphical Abstract:
Macrophages play an important role in the pathological development of different diseases. Therefore, macrophage targeting represents an important challenge in design of new medicines. This review gives a general presentation of small molecule-recognition concepts used for macrophage targeting. It describes mechanisms and systems for macrophage-targeted delivery, their obtaining and application.



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STARCH SULFURIC ACID: AN ALTERNATIVE, ECO-FRIENDLY CATALYST FOR BIGINELLI REACTION

Author(s):

Ramin Rezaei, Sara Malek, Mohammad Reza Sheikhi, Mohammad Kazem Mohammadi


Field: Organic chemistry
Type: Research paper
Issue: 2013 Volume 8, no.2
Pages: 101-106
Keywords: Biginelli reaction, dihydropyrimidinones, starch sulfuric acid, solvent-free, biodegradable catalys
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Abstract (PDF)

DOI:
dx.doi.org/10.19261/cjm.2013.08(2).13

Graphical Abstract:
 



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TASK-SPECIFIC IONIC LIQUIDS FOR EXTRACTIVE DESULFURIZATION OF DIESEL FUEL

Author(s):

Fliur Macaev, Eugenia Stîngaci


Field: Organic chemistry
Type: Short communication
Issue: 2013 Volume 8, no.2
Pages: 107-110
Keywords: task-specific ionic liquids, extractive desulphurization, diesel fuel
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Abstract (PDF)

DOI:
dx.doi.org/10.19261/cjm.2013.08(2).14

Graphical Abstract:
Task-specific ionic liquids based on imidazolium cation containing carbonitrile, carboxyl, and alkyl chains have been employed in an attempt to design new functionalized liquids for solvent extraction of sulphur compounds from diesel fuel.




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SYNTHESIS AND BIOLOGIC PROPERTIES OF SOME 1-(ALCHYL)PHENYL-3-(4-(3-(PYRIDIN-2-IL)ACRYLOYL)PHENYLTHIOUREA

Author(s):

A. Popusoi, N. Barba, A. Gulea, J. Roy, D. Poirier, V. Prisacari


Field: Organic chemistry
Type: Research paper
Issue: 2013 Volume 8, no.1
Pages: 83-89
Keywords: chalcones, isothiocyanatopropenones, thioureas, antibacterial activity, antifungal activity, antiproliferative activity.
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SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES

Author(s):

Z. Ribcovskaia, F. Macaev


Field: Organic chemistry
Type: Research paper
Issue: 2012 Volume 7, no.2
Pages: 136-142
Keywords: mono-substituted 1,3,4-oxadiazoles, symmetrically 2,5-disubstituted 1,3,4-oxadiazoles.
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DOI:
dx.doi.org/10.19261/cjm.2012.07(2).03

Graphical Abstract:
 
This article is an extended abstract of a communication presented at the Conference Ecological Chemistry 2012

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ZNCL2/ALCL3/SILICA (ZAS) AS AN EFFECTIVE HETEROGENEOUS CATALYST FOR THE SYNTHESIS OF 5-RYLOXYTETRAZOLES

Author(s):

F. Khamooshi and B. H. K. Jhaleh


Field: Organic chemistry
Type: Research paper
Issue: 2012 Volume 7, no.2
Pages: 130-135
Keywords: 5-Aryloxy tetrazoles, arylcyanates, guanyl azides, ZnCl 2 /AlCl 3 /silica (ZAS).
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2012.07(2).04

Graphical Abstract:
 A simple and efficient method for preparation of 5-aryloxy tetrazoles (3a-h) from arylcyanates (1a-h) with using ZnCl2/AlCl3/silica (ZAS) as an effective heterogeneous catalyst in solvent free are described with excellent yields and high purity. The rate of product formation was enhanced by introduction of electron donating substituents. The 1H NMR and chemical shifts and multiplicities are also discussed.

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SELECTIVE ORGANIC SYNTHESIS FOR SUSTAINABLE DEVELOPMENT

Author(s):

F. Macaev


Field: Organic chemistry
Type: Review
Issue: 2012 Volume 7, no.2
Pages: 67-77
Keywords: natural chiral hydrocarbons, ionic liquids.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2012.07(2).12

Graphical Abstract: 
The data on the development of selective organic synthesis suitable for obtaining multifunctional organic compounds both linear and cyclic structures using environmentally benign, inexpensive and renewable resources summarized.
This article is an extended abstract of a communication presented at the Conference Ecological Chemistry 2012.

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THE REACTIONS OF (+)-2- AND (+)-3-CARENES WITH THE RETENTION OF THE BICYCLIC FRAMEWORK

Author(s):

L. Bets, L. Vlad, F. Macaev


Field: Organic chemistry
Type: Review
Issue: 2010 Volume 5, no.2
Pages: 6-23
Keywords: (+)-2- carene, (+)-3-carene, trimethylbicyclo[4.1.0]heptanes, trimethylbicyclo[4.1.0]hept-3-enes, organic synthesis.
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IONIC LIQUIDS DERIVATIVE OF 1H-IMIDAZOLE AS NOVEL REAGENTS, CATALYSTS AND SOLVENTS

Author(s):

V. Sargorovschi, N. Sucman, T. Iudin, D. Duca, E. Stingaci, D. Prodius, S. Pogrebnoi, F. Macaev


Field: Organic chemistry
Type: Review
Issue: 2010 Volume 5, no.1
Pages: 36-56
Keywords: 1H-imidazole, ionic liquids, reagents, catalysts, solvents, organic synthesis.
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OPTICALLY ACTIVE CHRYSANTHEMIC ACID AND ITS ANALOGUES

Author(s):

L. Bets, Z. Ribkovskaia, L. Vlad, S. Pogrebnoi, F. Galin, F. Macaev


Field: Organic chemistry
Type: Review
Issue: 2010 Volume 5, no.1
Pages: 57-72
Keywords: chrysanthemic acid, pyrethrins, pyrethroids, permetrin, cypermethrin, deltamethrin (decis), thigalotrin (cyhalothin), natural (+)-3-carene, organic synthesis.
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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2010.05(1).04

Graphical Abstract:


Downloads: 25