Chemistry Journal of Moldova

2019 Volume 14, no.2

THE EFFECT OF SOLVENTS AND EXTRACTION PROCEDURE ON THE RECOVERY OF PHENOLIC COMPOUNDS AND THE ANTIOXIDANT CAPACITY OF ALGERIAN BASSIA MURICATA L. EXTRACTS

Author(s):

Hichem Mohammedi, Samira Idjeri-Mecherara, Fouad Menaceur, Aicha Hassani


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 79-89
Keywords: polyphenol, flavonoid, condensed tannin, antioxidant, Bassia muricata.
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DOI: http://dx.doi.org/10.19261/cjm.2019.637   
 
Abstract (PDF)
Graphical Abstract: This paper focuses on the study of the effect of extraction solvent choice on phenolic compounds contents and antioxidant activity of Bassia muricata. In this study, five different solvents namely: water, acetone, ethanol, methanol and hexane, and three extraction techniques were used to extract phenolic compounds: microwave-assisted extraction, Soxhlet and maceration. Total phenolics, total flavonoids and condensed tannins contents were determined. The results showed that different solvents with different polarity had a major effect on polyphenolic contents and antioxidant activity. Microwave-assisted extraction was the best suited for the extraction of antioxidant molecules when compared to Soxhlet and maceration.


 

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SYNTHESIS AND PRELIMINARY EVALUATION OF SEVERAL CHALCONE DERIVATIVES AS SUNSCREEN COMPOUNDS

Author(s):

Jumina Jumina, Rizky Woro Styaningrum, Dwi Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, Eti Nurwening Sholikhah, Abdul Karim Zulkarnain


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 90-96
Keywords: chalcone, photostability, absorbance, sunscreen, broad-spectrum.
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DOI: http://dx.doi.org/10.19261/cjm.2019.624   
 
Abstract (PDF)
Graphical Abstract: Four chalcone derivatives were synthesized and pre-evaluated as broad-spectrum UV protector. Chalcones 1-4 showed a wide range of UV absorbance values and moderate molar absorptivity values. Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB. 


 

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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL PYRAZOLE, IMIDAZOLE AND PYRIMIDINE DERIVATIVES POSSESSING IMIDAZO[4,5-B]INDOL MOIETY

Author(s):

Nadia Ali Ahmed Elkanzi, Amira Atef Ghoneim, Hajer Hrichi


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 105-116
Keywords: pyrazole, imidazole, pyrimidine, indol, antimicrobial activity.
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DOI: http://dx.doi.org/10.19261/cjm.2019.638   

Abstract (PDF)
Graphical Abstract: In this study, novel pyrazole, imidazole, pyrimidine derivatives bearing imidazo[4,5-b]indol moiety were successfully synthesized and their chemical structures were identified and confirmed by different spectral techniques. All the synthesized compounds were tested against four bacterial strains (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) and two fungi (Aspergillus flavus and Candida albicans). The obtained results show that the synthesized compounds could find fruitful applications as antibacterial and antifungal agents in pharmaceutical chemistry.


 

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PESTICIDES RESIDUE DETERMINATION IN VEGETABLES AND FRUITS COMMONLY USED IN REPUBLIC OF MOLDOVA AND ESTIMATION OF HUMAN INTAKE

Author(s):

Raisa Sircu, Gheorghii Turcanu, Nicolae Opopol, Iurie Pinzaru, Tatiana Manceva, Raisa Scurtu


Field: Ecological chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 62-71
Keywords: pesticide residue, fruit, vegetable, estimated daily intake, risk assessment.
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DOI: http://dx.doi.org/10.19261/cjm.2019.584   
 
Abstract (PDF)
Graphical Abstract: A total of 5206 samples from twenty-one different vegetables and fruits were collected. Residues of pesticides in concentrations exceeding the maximum residue levels were found in 22.9% of analysed samples. Thirteen insecticides, four fungicides, two acaricides and one herbicide were detected in the analysed samples. The highest value of hazard index was calculated for diazinon – 0.15. The obtained results show that the long-term consumption of vegetables and fruits could pose a health risk for the population of the Republic of Moldova.


 


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EFFECT OF TEMPERATURE ON GREEN SYNTHESIS OF SILVER NANOPARTICLES USING VITEX AGNUS-CASTUS EXTRACT

Author(s):

Oksana Stavinskaya, Iryna Laguta, Tetiana Fesenko, Marina Krumova


Field: Ecological chemistry
Type: Short communication
Issue: 2019 Volume 14, no.2
Pages: 117-121
Keywords: nanoparticle, silver, green synthesis, Vitex agnus-castus extract.
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DOI: http://dx.doi.org/10.19261/cjm.2019.636   
 
Abstract (PDF)
Graphical Abstract: Silver nanoparticles colloids were prepared using the extract from the leaves of Vitex agnus-castus. The effect of temperature on the reduction of silver ions and on the growth of silver nanoparticles was followed by measuring the intensity of the surface plasmon resonance band in the UV spectra. It was found that fast reduction of silver ions occurs even at 40°C, while effective synthesis of silver nanoparticles requires elevated temperatures of 60-80°C.


 


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MULTI-COMPONENT REACTION SYNTHESIS OF 1,6-DIAMINO-2-OXO-1,2,3,4-TETRAHYDROPYRIDINE-3,5-DICARBONITRILES USING ULTRASONICATION AND DMAP AS CATALYST

Author(s):

Maryam Shokoohian, Nourallah Hazeri, MalekTaher Maghsoodlou, Mojtaba Lashkari


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 97-104
Keywords: one-pot reaction, multi-component reaction, pyridine-2(1H)-one derivative, ultrasonication, 4-(dimethylamino)pyridine.
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DOI: http://dx.doi.org/10.19261/cjm.2019.639   

Abstract (PDF) 
Supplementary Material (PDF)
Graphical Abstract: 4-(Dimethylamino)pyridine was found to be an efficient homogenous catalyst for one-pot multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%.
 


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RECENT STUDIES OF (+)-3-CARENE TRANSFORMATIONS WITH THE RETENTION OF THE NATIVE FRAMEWORK

Author(s):

Serghei Curlat


Field: Organic chemistry
Type: Review
Issue: 2019 Volume 14, no.2
Pages: 32-55
Keywords: (+)-3-carene, epoxidation, sulphide, aminoalcohol, azidoalcohol, aziridine.
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DOI: http://dx.doi.org/10.19261/cjm.2019.616   
 
Abstract (PDF)
Graphical Abstract: This review presents last decade and some past especially relevant studies in the field of (+)-3-carene synthetic transformations. This paper discusses exclusively the transformations of (+)-3-carene, proceeding with the retention of the native bicyclic carbon skeleton. The data concerning the features of epoxidation and oxidation reactions of (+)-3-carene, the synthesis of sulphur- and selenium-containing derivatives and their use in asymmetric synthesis are given. It also describes methods for producing amino derivatives of (+)-3-carene, substituted heterocycles based on it, reactions for the preparation of aziridines, azido-alcohols and azidoamines, as well as chiral phosphites as bidentate ligands.


 

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SYNTHESIS OF NEW DI- AND TRINORLABDANE COMPOUNDS WITH 2-AMINO-1,3-THIAZOLE UNITS

Author(s):

Svetlana Blaja


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 72-78
Keywords: synthesis, di-norlabdane, tri-norlabdane, 2-amino-1,3-thiazole, cyclization reaction.
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DOI: http://dx.doi.org/10.19261/cjm.2019.609   
 
Abstract (PDF)
Graphical Abstract: TThe present paper reports the synthesis of new hybrid terpeno-heterocyclic compounds belonging to di- and tri-norlabdane series. Starting from natural labdane diterpenoide (-)-sclareol, via its intermediates 8α-hydroxy-15,16-dinorlabd-13-one and sclareolide, two di-norlabdane and three tri-norlabdane, previously unreported compounds possessing 2-amino-1,3-thiazole structural units were obtained in three and four steps, respectively, with acceptable to good overall yields. The structures of newly obtained compounds were confirmed by means of spectral IR, 1H and 13C NMR analyses.


 

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DEVELOPMENT AND VALIDATION OF AN ASSAY METHOD FOR CIPROFLOXACIN HYDROCHLORIDE DETERMINATION IN COMBINATION EAR DROPS

Author(s):

Livia Uncu, Elena Donici, Vladimir Valica, Oxana Vîslouh, Veaceslav Gonciar, Sergiu Parii


Field: Analytical chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 56-61
Keywords: ciprofloxacin hydrochloride, UV-Vis spectroscopy, validation, ear drop, Ocimum basilicum.
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DOI: http://dx.doi.org/10.19261/cjm.2019.607   
 
Abstract (PDF)
Graphical Abstract: A simple, precise and accurate UV-Vis spectrophotometric method has been developed and validated for the estimation of ciprofloxacin hydrochloride from combination ear drops with basil oil (Ocimum basilicum). The results of the validation of the method demonstrate that the developed method is simple, rapid, accurate and robust over the concentration range 2-10 μg/mL of ciprofloxacin hydrochloride in combination with volatile basil oil.


 

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NATURAL PRODUCTS FROM MARINE HETEROBRANCHS: AN OVERVIEW OF RECENT RESULTS

Author(s):

Margherita Gavagnin, Marianna Carbone, Maria Letizia Ciavatta, Ernesto Mollo


Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2019 Volume 14, no.2
Pages: 9-31
Keywords: marine mollusk, natural product, chemical ecology, bioprospecting.
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DOI: http://dx.doi.org/10.19261/cjm.2019.617   
 
Abstract (PDF)
Graphical Abstract: Heterobranchs are a fascinating group of marine mollusks that are recognized as an important source of bioactive natural products. Often, these molecules, which are either selected from the diet or de novo biosynthesized by the mollusks, play a fundamental role for their survival being utilized as defensive chemicals against predators. A summary of the studies carried out, in the last decade, on heterobranchs is presented here. A number of new compounds exhibiting different molecular architectures were chemically characterized. 


 

Downloads: 24