Chemistry Journal of Moldova

SYNTHESIS OF NEW DI- AND TRINORLABDANE COMPOUNDS WITH 2-AMINO-1,3-THIAZOLE UNITS

Author(s):

Svetlana Blaja


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 72-78
Keywords:

synthesis, di-norlabdane, tri-norlabdane, 2-amino-1,3-thiazole, cyclization reaction.


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DOI: http://dx.doi.org/10.19261/cjm.2019.609   
 
Abstract (PDF)
Graphical Abstract: TThe present paper reports the synthesis of new hybrid terpeno-heterocyclic compounds belonging to di- and tri-norlabdane series. Starting from natural labdane diterpenoide (-)-sclareol, via its intermediates 8α-hydroxy-15,16-dinorlabd-13-one and sclareolide, two di-norlabdane and three tri-norlabdane, previously unreported compounds possessing 2-amino-1,3-thiazole structural units were obtained in three and four steps, respectively, with acceptable to good overall yields. The structures of newly obtained compounds were confirmed by means of spectral IR, 1H and 13C NMR analyses.


 

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