Chemistry Journal of Moldova

STEROIDAL GLYCOSIDES FROM THE SEEDS OF HYOSCYAMUS NIGER L. AND THEIR ANTIFUNGAL ACTIVITY

Author(s):

Irina Lunga, Pavel Chintea, Stepan Shvets, Anna Favelb and Cosimo Pizza


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2007 Volume 2, no.1
Pages: 108-113
Keywords:

Hyoscyamus niger L., steroidal glycosides, antifungal activity.


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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2007.02(1).05

Graphical Abstract:
 Phytochemical analysis of the seeds of Hyocyamus niger L. (Solonaceae) resulted in the isolation of six steroidal glycosides, two furostanol (1, 2) and four spirostanol saponins (3, 4, 5, 6), which were found in this plant for the first time. The structures of these compounds were determined by detailed analysis of their spectral data, including two-dimensional NMR spectroscopy and MS spectroscopy. The antifungal activity of a crude steroidal glycoside extract, fractions of spirostanoles and individual glicosides was investigated in vitro against a panel of human pathogenic fungi, yeasts as well as dermatophytes and filamentous species.

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