Chemistry Journal of Moldova

SIMULTANEOUS QUANTITATIVE ESTIMATION OF LISINOPRIL AND HYDROCHLOROTHIAZIDE RESIDUES USING HPLC FOR CLEANING VALIDATION

Author(s):

Imeda Rubashvili, Natela Karukhnishvili, Khatuna Makharadze


Field: Analytical chemistry
Type: Research paper
Issue: 2020 Volume 15, no.1
Pages: 8-21
Keywords:

lisinopril, hydrochlorthiazide, swab sampling, rinse sampling, HPLC, validation.


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DOI: http://dx.doi.org/10.19261/cjm.2020.669   
 
Abstract (PDF)
Graphical Abstract: A new, rapid and selective, HPLC method for simultaneous quantitative estimation of lisinopril and hydrochlorothiazide residues and sampling procedures from pharmaceutical manufacturing equipment surfaces were developed and validated. The sampling procedures have a good recovery (>80%). The limit of quantitation of the HPLC method - 0.155 µg/mL and 0.025 µg/mL for lisinopril and hydrochlorothiazide, respectively. 


 

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