Chemistry Journal of Moldova

NOVEL β-LACTAMS AND THIAZOLIDINONE DERIVATIVES FROM 1,4-DIHYDROQUINOXALINE SCHIFF’S BASE: SYNTHESIS, ANTIMICROBIAL ACTIVITY AND MOLECULAR DOCKING STUDIES

Author(s):

Hajer Hrichi, Nadia Ali Ahmed Elkanzi, Rania Badawy Bakr


Field: Organic chemistry
Type: Research paper
Pages: 9
Keywords:

heterocycle, β-lactam, quinoxaline, antimicrobial activity, molecular docking.


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DOI: http://dx.doi.org/10.19261/cjm.2019.647   
 
Graphical Abstract: A series of novel isolated β-lactams 3a-c and thiazolidinone derivatives 4a-c were successfully synthesized from reactions of new Schiff's bases 2a-c with chloroacetyl chloride and thioglycolic acid. The chemical structures of the new compounds were confirmed through different spectroscopic techniques including IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. The antimicrobial activity of the obtained compounds was assessed in-vitro against gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacteria and Aspergillus flavus and Candida albicans fungi. Furthermore, a molecular docking study was carried out and the results indicated that compounds 3b and 4b displayed comparable binding affinity scores as that of glutamate. These two compounds are promising candidates as antibacterial and antifungal agents that would deserve further investigations.



 

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