Chemistry Journal of Moldova

MULTI-COMPONENT REACTION SYNTHESIS OF 1,6-DIAMINO-2-OXO-1,2,3,4-TETRAHYDROPYRIDINE-3,5-DICARBONITRILES USING ULTRASONICATION AND DMAP AS CATALYST

Author(s):

Maryam Shokoohian, Nourallah Hazeri, MalekTaher Maghsoodlou, Mojtaba Lashkari


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 97-104
Keywords:

one-pot reaction, multi-component reaction, pyridine-2(1H)-one derivative, ultrasonication, 4-(dimethylamino)pyridine.


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DOI: http://dx.doi.org/10.19261/cjm.2019.639   

Abstract (PDF) 
Supplementary Material (PDF)
Graphical Abstract: 4-(Dimethylamino)pyridine was found to be an efficient homogenous catalyst for one-pot multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%.
 


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