Chemistry Journal of Moldova

A SEQUENTIAL DUAL CLEAVAGE OF THE ARYLSULFAMATE LINKER TO PROVIDE BOTH SULFAMATE AND PHENOL DERIVATIVES

Author(s):

Diane Fournier, Liviu Ciobanu, Donald Poirier


Field: Organic chemistry
Type: Research paper
Issue: 2015 Volume 10, no.2
Pages: 68-76
Keywords:

solid-phase synthesis, linker, sulfamate, phenol, library.


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Abstract (PDF)

DOI:
dx.doi.org/10.19261/cjm.2015.10(2).09

Graphical Abstract:
 Tyramine sulfamate was linked to the trityl chloride resin and this polymeric support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split) two types of compounds (phenol and arylsulfamate derivatives), which are therapeutically attractive types of compounds.


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